Objective?To seek good markers to predict invasion and metastasis of gastric adenocarcinoma (GAC). Methods?Expression of Kangai 1 (KAI1), CD34, and D2-40 were examined by immunohistochemistry containing 145 specimens of GAC and 50 specimens of normal gastric tissue. Microvessel density (MVD) and lymph vessel density (LVD) were determined by the mean number of small CD34-positive or D2-40-positive vessels counted. And the relationship of KAI1, MVD and LVD, as well as the role of them on invasion, metastasis and prognosis in GAC were analyzed. Results?The positive rate of KAI1, the median scores of MVD and LVD in normal gastric tissue and GAC tissue were 92.0%, (9.2±7.8)/LP, (7.5±7.6)/LP and 37.2%, (21.6±9.1)/LP, (22.6±12.7)/LP, respectively. And there was a significant different between the two groups (PPPPP
