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论文摘要

基于创新中医理论辨证施治慢性肾脏疾病的临床研究

Management of Chronic Kidney Disease Guided by the Theory of Traditional Chinese Medicine: an Experimental Study

作者:文集, 谢席胜, 张明华等

Author:WEN Ji, XIE Xi-sheng, ZHANG Ming-hua. et al

收稿日期:          年卷(期)页码:2014,45(1):34-38

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:中药方剂 慢性肾脏疾病 肾小球滤过率 蛋白尿[HT7"]

Key words:Chinese medicine prescription Chronic kidney disease Glomerular filtration rate Proteinuria

基金项目:

中文摘要

目的 探索在中医理论辩证原则下使用辨证施治对比中成药配合西药治疗慢性肾脏疾病的临床疗效。方法 纳入同期门诊慢性肾脏疾病患者共225例,其中纳入接受了常规西药加中成药治疗患者170例作为对照组,纳入接受常规西药治疗配合中医理论"肾痿"治疗的患者55例作为治疗组。比较两组患者的治疗结局,并采用多元线性回归分析影响治疗结局的因素。结果 治疗组和对照组的基线数据在年龄 (PP=0.007)和蛋白尿程度 (PPP=0.475)。治疗组和对照组对尿蛋白 (P=0.058)和尿红细胞 (P=0.577)的影响无差异,对尿白细胞的影响亦不明显 (P=0.01)。治疗组相比对照组治疗后更多患者出现了估算肾小球滤过率上升 (PPP=0.008)。相比于肾功能分期 (标准化回归系数0.165),分组 (标准化回归系数0.395)对治疗结局的影响更大。结论 常规西药治疗配合中医理论的"肾痿"辨证施治可以改善慢性肾脏疾病患者的肾小球滤过率,在肾功能分期严重的患者中更为明显,且疗效优于常规西药加中成药治疗。

英文摘要

Objective?To determine the impact of Traditional Chinese Medicine on patients with chronic kidney disease (CKD). Methods?A total of 225 CKD patients in an outpatient department were recruited for this study, among whom 170 received regular Western and Chinese medicine treatments (control group) and 55 received treatments guided by the theory of Traditional Chinese Medicine (experimental group). The effectiveness of the treatments was determined through a pre-post comparison. Results?Significant pre-intervention differences in age (PP=0.007) and urine protein (PPPP=0.475), urine protein (P=0.058), urine red cells (P=0.577), and urine white cells (P=0.01). A greater level of increase in estimated glomerular filtration rate was found in the experimental group compared with the control (PB=0.395, PB=0.165, P=0.008) as significant predictors on the outcomes of treatment. Conclusion?The treatment of CKD patients guided by the theory of Traditional Chinese Medicine can improve renal function through influencing glomerular filtration rate. The effect is more prominent than the regular treatment regime.

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