Objective?To determine the impact of Traditional Chinese Medicine on patients with chronic kidney disease (CKD). Methods?A total of 225 CKD patients in an outpatient department were recruited for this study, among whom 170 received regular Western and Chinese medicine treatments (control group) and 55 received treatments guided by the theory of Traditional Chinese Medicine (experimental group). The effectiveness of the treatments was determined through a pre-post comparison. Results?Significant pre-intervention differences in age (PP=0.007) and urine protein (PPPP=0.475), urine protein (P=0.058), urine red cells (P=0.577), and urine white cells (P=0.01). A greater level of increase in estimated glomerular filtration rate was found in the experimental group compared with the control (PB=0.395, PB=0.165, P=0.008) as significant predictors on the outcomes of treatment. Conclusion?The treatment of CKD patients guided by the theory of Traditional Chinese Medicine can improve renal function through influencing glomerular filtration rate. The effect is more prominent than the regular treatment regime.