期刊导航

论文摘要

超重对绝经后乳腺癌芳香化酶抑制剂临床疗效的影响

作者:谭秋雯, 张俊慧, 梁法清, 钟晓蓉, 吕青

Author:, , , ,

收稿日期:2018-11-05          年卷(期)页码:2019,50(3):405-408

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:超重, 肥胖, 乳腺癌, 芳香化酶抑制剂, 内分泌治疗

Key words:, , , ,

基金项目:

中文摘要

目的 研究体质量对绝经后乳腺癌患者芳香化酶抑制剂(aromatase inhibitors, AIs)疗效的影响,为超重及肥胖的乳腺癌患者的系统治疗提供依据。 方法 回顾性分析2001~2011年于四川大学华西医院乳腺外科就诊的女性绝经后激素受体阳性、且使用AIs为初始内分泌治疗的乳腺癌患者,纳入初诊体质量指数(body mass index,BMI)≥ 24 kg/m2 的乳腺癌患者为超重组,按1∶1比例配对(包括确诊年龄、确诊年限、Luminal A或Luminal B分子分型、及服用AIs药物的类型)的正常BMI乳腺癌患者(18.5 kg/m2<BMI <24 kg/m2)为对照。主要研究指标包括内分泌治疗抵抗率、无病生存(disease-free survival, DFS) 率及总生存 (overall survival, OS) 率。 结果 超重组及对照组乳腺癌患者各182例,截止2016年1月,中位随访时间为75月。两组患者平均BMI分别为26.44、21.62 kg/ m2。超重组及对照组乳腺癌患者内分泌治疗抵抗比例分别为12.09% (22/182)及6.59% (12/182) (P = 0.072)。其中超重组患者继发性内分泌治疗抵抗升高 (7.14% vs. 2.75%, P = 0.042),但两组DFS率及OS率差异均无统计学意义。 结论 超重可增加绝经后激素受体阳性乳腺癌患者AIs继发性内分泌治疗抵抗发生率,但对其生存无明显影响。

英文摘要

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