Objective To investigate the clinical characteristics, metabolic status, insulin resistance and insulin secretory function of diabetic patients with early onset. Methods The study was undertaken in the West China Hospital of Sichuan University. Characteristics of 342 admitted diabetic patients with early onset (EOD group, diagnosed at age 15-45 years old) were reviewed and compared with 296 admitted patients with late onset (LOD group, diagnosed at age＞45 years old). All of the participants had negative islet autoantibodies. Homeostasis model assessment 2 of insulin resistant (HOMA2-IR) and HOMA2 of insulin sencitivity (HOMA2-%S) were measured to estimate insulin resistance and insulin sensitivity. HOMA2 of β-cell function (HOMA2-%β) index was used to estimate β-cell secretory function. We also compared clinical characteristics and metabolic status between the two groups. Results EOD patients were more likely to have ketosis,ketoacidosis, insulin therapy and positive diabetic family history than LOD patients (PPPP
