Objective To determine the feasibility and clinical efficacy of ultrasound-guided facet joint injection and nerve block in lumbar facet joint for the treatment of facet-joint related low back pain. Methods 20 patients with facet-joint pain were randomized into two groups received block blindly(B group) or guided by ultrasound (US group) respectively. The location of needle tip was confirmed by CT in both groups, and the accuracy was computed afterwards. VAS score, puncture time and one-time puncture success rate(%) were recorded. VAS scores and pain remission rates in both groups were recorded at 30 min, 1 d, 2 d, 6 weeks after the block. Results The VAS scores were 3.3±0.4 in US group and 1.2±0.3 in B group (PPPPP>0.05). After 6 weeks of follow-up, the overall remission rates were (72.3±14.0)% in US group, and (56.7±11.0)% in B group, there was no significant difference between the two groups (P>0.05). Conclusion The ultrasound-guided lumbar facet joint injection technique had a high feasibility and accuracy, and had better clinical efficacy than block blindly.