Objective To establish a new reliable experimental abdominal aortic aneurysm (AAA) rat model that simulates human aneurysms and has high survival rate. Methods Twenty-four SD rats were randomly divided equally into two groups (male∶female=1∶1). Intraluminal saline infusion was given to rats in group A. Rats in group B were given intraluminal elastase infusion and extraluminal calcium chloride application. The diameter of abdominal aorta was measured and eventually harvested at 4 weeks. Successful AAA formation was defined as a dilation ratio >50%. HE stain was applied to evaluate the histology changes of aorta. Results Group A had a survival rate, technical success rate and AAA formation rate of 83.3%, 91.67%, and 0% respectively, compared with 91.67%, 100%, and 90.91% in group B. The AAA formation rate in group B was significantly higher than that in group A (PP
