Objective To investigate the correlation of serum leptin and to energy consumption and metabolization in the patients with chronic obstructive pulmonary disease (COPD). Methods We included 92 outpatients with stable COPD in West China Hospital of Sichuan University as trail group (COPD group) and 80 healthy elderly people in community as control group. All patients and healthy control received the measurements of body mass index (BMI), fat mass, resting energy expenditure （REE）, lung function, serum leptin and tumor necrosis factor-α （TNF-α）. Results The concentrations of serum leptin, BMI and lung function were lower in COPD group than those in control group （P
