迟发型类风湿关节炎的疾病活动特征及治疗现状分析

Disease Activity and Therapeutic Strategy of Patients with Late-onset Rheumatoid Arthritis

作者：杨闵, 梁燕, 岑筱敏等

Author：YANG Min, LIANG Yan, CEN Xiao-min. et al

收稿日期： 年卷（期）页码：2015,46(2):289-292

期刊名称：四川大学学报（医学版）

Journal Name：JOURNAL OF SICHUAN UNIVERSITY （MEDICAL SCIENCE EDITION）

关键字：迟发型类风湿关节炎早发型类风湿关节炎疾病活动度治疗

Key words：Late-onset rheumatoid arthritisYounger-onset rheumatoid arthritisDisease activity

基金项目：

中文摘要

目的比较迟发型类风湿关节炎（LORA）与早发型类风湿关节炎（YORA）的临床特征与治疗现状，探讨LORA疾病特点。方法回顾性分析259例类风湿关节炎患者病历资料。LORA与YORA分界为发病年龄是否≥60岁。比较患者性别比、病程、受累关节特征、关节外表现、实验室检查、疾病活动评分及治疗策略的差异，分析LORA疾病特征。结果 LORA患者性别比（男/女）1/1.88,性别差异缩小（\P=0.009），发病至确诊时间较YORA长（\P\P\P\P\P=0.002）。67.4%的LORA患者使用了糖皮质激素治疗，高于YORA（29.3%，\P\P

英文摘要

Objective To compare the disease activity and therapeutic strategy of late-onset rheumatoid arthritis （LORA）with young-onset rheumatoid arthritis （YORA）. Methods Medical records of 259 patients with rheumatoid arthritis (RA) were reviewed retrospectively. The cut-off between LORA and YORA was operationally set at 60 years of age at disease onset. Gender ratio, disease duration, feature of involved joint, extra-articular features, laboratory features, disease activity score and treatment strategy were compared between LORA and YORA. Results The LORA patients had a gender ratio (male/female) of 1/1.88, which was approaching 1/1 in the older age group. It took longer for LORA to be diagnosed than YORA (\P\P\P\P\P=0.002). Glucorcoticoid was used in 67.4% LORA patients, compared with 29.3% in YORA patients (\P\P

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论文摘要

迟发型类风湿关节炎的疾病活动特征及治疗现状分析

Disease Activity and Therapeutic Strategy of Patients with Late-onset Rheumatoid Arthritis