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论文摘要

USP9X在非小细胞肺癌中的表达及与临床病理特征的关系

Expression of USP9X in Non-small Cell Lung Cancer and Its Clinical Significance

作者:彭静, 胡倩, 刘卫平等

Author:PENG Jing, HU Qian, LIU Wei-ping. et al

收稿日期:          年卷(期)页码:2015,46(3):413-416

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:肺肿瘤 USP9X 生存 免疫组化

Key words:Lung neoplasms USP9X Survival Immunohistochemistry

基金项目:

中文摘要

目的 探讨泛素特异性蛋白酶9X(USP9X)蛋白在非小细胞肺癌(NSCLC)及肺良性病变组织中的表达特点及其临床意义。方法 采用免疫组织化学染色方法检测71例NSCLC及20例肺良性病变组织中USP9X蛋白的表达,并分析其中51例NSCLC患者肺癌组织标本中USP9X的表达与患者临床病理特征及预后的关系。结果 NSCLC患者USP9X的阳性表达率为69.0%(49/71),较肺良性病变患者阳性表达率20.0%(4/20)高,差异有统计学意义(PP均PP均

英文摘要

Objective To investigate the expression and clinical significance of ubiquitin-specific protease 9X (USP9X) protein in non-small cell lung cancer (NSCLC). Methods USP9X proteins were detected in 71 cases of NSCLC and 20 cases of benign pulmonary tissues by immunohistochemical staining. The correlation between USP9X expression and 51 NSCLC clinicopathological parameters as well as survival rates were indicated. Results Higher rate 〔69.0% (49/71)〕 of the expression of USP9X was observed in NSCLC samples, compared with 20.0% (4/20) in benign pulmonary tissues (PPPP

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