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论文摘要

乳化七氟烷选择性阻滞外周神经对骨骼肌松弛作用的研究

The Effect of Emulsified Sevofluran on Muscular Relaxation through Selective Blockage of Peripheral Nerves

作者:叶菱, 孙辛欣, 朱涛等

Author:YE Ling, SUN Xin-xin, ZHU Tao. et al

收稿日期:          年卷(期)页码:2016,47(4):522-526

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:乳化七氟烷 选择性麻醉模型 骨骼肌松弛

Key words:Emulsified sevofluran Selective anesthetics delivery models Muscle relaxation

基金项目:

中文摘要

目的 探索七氟烷松弛骨骼肌作用的位点是否位于外周神经。方法 健康新西兰大白兔36只,随机分配到乳化七氟烷低浓度组〔4 mL/(kg·h)〕、中浓度组〔6 mL/(kg·h)〕、高浓度组〔10 mL/(kg·h)〕及脂肪乳对照组〔以10 mL/(kg·h)的速率泵入30%脂肪乳〕,每组9只。选择性麻醉下肢外周神经、神经-肌肉接头及骨骼肌肌纤维;模型建立成功后,比较麻醉前后所测得胫骨前肌静息张力和肌肉收缩力的变化。结果 七氟烷低、中、高浓度组七氟烷分压在股静脉与颈内静脉之间的差异均具有统计学意义( P P

英文摘要

Objective To identify the site that emulsified sevoflurane influences in the nerve system. Methods Thirty-six healthy New Zealand rabbits were randomly and equally divided into low concentration emulsified sevoflurane group 〔4 mL/(kg·h)〕, medium concentration 〔6 mL/(kg·h)〕group, high concentration group〔10 mL/(kg·h)〕and intralipid control group. Emulsified sevoflurane was infused through arterial to selectively block peripheral nerves, neuro-muscular junctions and muscle fibers. The anterior tibial muscle resting tensions and muscle contraction forces were compared before and after the infusions. Results Significant differences of blood sevoflurane pressure between femoral veins and internal jugular veins appeared in rabbits in all the groups ( P P

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