【Abstract】 Objective To determine the value of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in the diagnosis of placenta residue with implantation. Methods We retrospectively analyzed 112 cases of placenta remnants from Apr. 2013 to Mar. 2016, all of which were confirmed by pathological results. The cases were divided into implanted (n =74) and non-implanted (n =38) groups. We compared the characteristics of US and CEUS imaging between the two groups. Multi-variate logistic regression models were established to assess the accuracy of ultrasound imaging in predicting implantation, including the area under the curve (AUC ) of receiver operating characteristic (ROC) curves. Results US detected intrauterine lesions, with significant differences between the two groups in the clearness of boundaries of lesions (P P P AUC of CEUS (0.922) and US+CEUS (0.952) were also significantly higher than that of US (0.887) (P