In view of the micro-mechanical property of copper alloy fabricated by selective laser melting (SLM), the effects of different processing parameters (laser power, scanning speed and scanning space) on the nanoindentation hardness were researched according to the orthogonal experimental design test method. Based on the analysis of variance, the impact degree of diverse processing parameters on the nanohardness was obtained, which could provide a theoretical direction for improving the micro-mechanical property of parts during SLM.