Abstract:Using Response Surface Methodology(RSM), selecting Quadratic model, on the basis of model Box-Behnken experiment design optimization in NH3-(NH4)2SO4-H2O system leaching of zinc oxide ore experiment process parameters, and the regression equation is established.Regression analysis model of "Prob>F" value of 0.0023, less than 0.05, the model of high precision, all between independent variable and dependent variable of the regression equation is significant, regression equation to be trusted. Model analysis found that the liquid-solid ratio, leaching temperature, leaching time, the three factors that affect the leaching rate of zinc is significant, the analysis of the response surface and contour plot, liquid-solid ratio and the leaching time of interaction is significant.RSM analysis ,the optimum leaching conditions were obtained as follows: liquid-solid ratio 12.81, leaching temperature 30 ℃, leaching time of 4.15 h, total ammonia concentration of 7.5 mol?L-1, predicting leaching rate was 86.2%.Considering the feasibility of the operation, in the NH3-(NH4)2SO4-H2O system leaching process of zinc oxide ore, selected liquid-solid ratio 13, leaching time 4h, leaching temperature 30 ℃, total ammonia concentration of 7.5 mol?L-1, measured the leaching rate was 86.0%, compared with the theoretical prediction error is 0.23%.