Abstract: We configured a solution (TASLN) of 10mg/ml total alkaloids of Liparis nervosa (TALN), which was extracted by Ultrasonic-assisted method. Normal saline (NS) was used as blank control and Yunan Baiyao as control in experience. For coagulation in vivo, the object was mice and we measured the bleeding time and the amount of bleeding. For coagulation in vitro, the object was rabbits. We recorded the hemostasis time of wound. the rabbits' anticoagulant blood was used to measure the coagulation time, prothrombin time (PT), Recalcification time (RT), respectively. The results showed that the time and the amount of mice bleeding was 212.95s and 42.5 square. The coagulation time was 192.23s by blood congeals method and 245.48s by tube method, PT and RT of rabbits' blood of TALN was 12.22s and 180.78s, all the times were shorter than the blank control. The average hemostasis time of total alkaloids solution of Liparis nervosa (81.50s) was obviously shorter than that of NS (125.20s), but showed no significant difference with that of Yunnan Baiyao (75.20s). The TALN shows obvious coagulation activity.
