非编码RNA调控人牙周膜干细胞成骨向分化的研究进展

Periodontitis is a common inflammatory disease that is characterised by progressive damage to dental supporting structure. Periodontitis is the main cause of tooth loss in adults in China. The aim of periodontal treatment is not only to control inflammation and prevent disease development but also to obtain periodontal regeneration. Human periodontal ligament stem cells (PDLSCs), which are capable of osteogenic differentiation, are expected to play important roles in clinical application of periodontal tissue repair and regeneration. Non-coding RNAs (ncRNAs) generally refer to RNAs that do not encode proteins. The continuous development of high-throughput detection techniques has allowed the identification of a large number of ncRNAs and their biological functions. Increasing numbers of ncRNAs have been reported to function in the pathogenesis of diseases at molecular and cellular levels. Therefore, research on ncRNAs can provide new insights into periodontal regeneration. This review focuses on the regulatory mechanism of several ncRNAs in the osteogenic differentiation of human PDLSCs.