Enamel demineralization is a regular dental harm in orthodontic clinic, which often affect the health and aesthetic of teeth. Once demineralization occurs, mostly can not be reversed. The application of fluoride to preventing demineralization is comm only recognized, that can restrain enamel demineralization and promote enamel remineralization. The main principles are reducing enamel solubility, creating calcium fluoride and fluoride phosphorate to promote remineralization. Fluoride has many categories, and the comm only use are reviewed as follows.
