Arginine, glycin and aspastic acid make up of the RGD sequence, which is found in many extracellular matrix. About 11 integrins have been shown to bind to extracellular matrix molecules in a RGD dependent manner. RGD effectively improved the adhesion of cells to biomaterials. To immobilize the RGD sequence onto titanium material implant surfaces can promote the adhesion of osteoblast to titanium material surfaces, further improve implant osseointegration, and increase success rate of implant. The space structure, density and ambient sequence of RGD play roles in activity of RGD. This paper reviewed the biological effect, application and influence factors in implant osseointegration.
