Glucose transporter - 1(GLUT- 1) is the main carrier protein of transporting the glucose in mammalian cell, which is closely correlated with metabolism. In recent research, it is found that GLUT- 1 is the special symbol of endothelial cell of the infant hemangiomas. Therefore, the development and significance of the expression of GLUT- 1 in infant hemangiomas will be summarized in this article.