Streptococcus mutans is known as a primary pathogen of dental caries, it not only has an advantage over amount, but also has a strong ability to produce and resist acid. However, forming biofilms to adhere to the surface of the teeth is the most important step. The caseinolytic protease is a kind of heat shock protein, which mediates the proteolysis. This protease can remove the denatured proteins in the bacterial and play a particular role in biofilm formation and stress response reaction of the bacterial.
