Ni-Cr合金对人口腔颊黏膜细胞遗传毒性的初步临床研究
A preliminary clinical study of genotoxicity in oral mucosa cells exposed to Ni-Cr alloy
作者：林国芬 陈志红 刘丽
Author：Lin Guofen, Chen Zhihong, Liu Li.
收稿日期：2012-12-27 年卷（期）页码：2013,40(4):444-446
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：Ni-Cr合金,微核率,微核细胞率,微核试验,遗传毒性,
Key words：Ni-Cr alloy,micronuclei frequency,micronucleated cell frequency,micronucleus assay,genotoxicity,
基金项目：
浙江省自然科学基金资助项目（LY12H14001）； 浙江省教育厅科研计划基金资助项目（Y201122515）
中文摘要
目的 初步研究Ni-Cr合金对人口腔颊黏膜细胞的遗传毒性。方法 选取68名患者作为研究对象， 分为暴露组34名和对照组34名。采集2组患者口腔颊黏膜细胞进行微核试验， 计算细胞微核率（MNF）和微核细胞率（MCF）。结果 暴露组颊黏膜MNF和MCF分别为1.63‰±2.03‰和1.26‰±1.42‰， 对照组MNF和MCF分别为1.57‰±1.88‰和1.06‰±1.16‰， 2组之间差异无统计学意义（P>0.05）。结论 人群调查口腔颊黏膜微核试验未检测出使用Ni-Cr合金患者的口腔黏膜细胞有明显的遗传损伤。
英文摘要
Objective The aim of the study was to assess the genotoxicity in oral mucosa cells exposed to Ni-Cr alloy.Methods Sixty-eight subjects were divided into two groups, including 34 subjects of exposure group and 34 subjects of control group. The genotoxicity in oral mucosa cells were assessed by micronucleus assay. Micronuclei frequency（MNF） and micronucleated cell frequency（MCF） were calculated.Results Micronucleus assay revealed that the MNF and MCF of oral mucosa cells in exposure group were 1.63‰±2.03‰ and 1.26‰±1.42‰, while the MNF and MCF were 1.57‰±1.88‰ and 1.06‰±1.16‰ in control group respectively. There were no significant differences（P>0.05） between two groups.Conclusion The results suggested that there was no significant genotoxicity in oral mucosa exposed to Ni-Cr alloy by micronucleus assay.
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