Objective To observe the line of cleft palate patients with velopharyngeal muscle flap pharyngoplasty postoperative oxygen inhalation of adverse reactions and the effect of nursing intervention. Methods 50 patients after velopharyngeal muscle flap pharyngoplasty surgery were randomly divided into control group and observation group, 25 cases were given oxygen aerosol inhalation and systemic anti-inflammatory treatment. The observation group was treated with intermittent atomization inhalation and targeted the anxiolytic care intervention. Results Two groups of patients with chest tightness, rapid heart rate, shortness of breath, dizziness and other adverse reaction rates and anxiety and the incidence was statistically significant(P