ObjectiveThis study investigated the effects of self-efficacy intervention on the psychological state of orthodontic patients and established a reasonable intervention model to enhance clinical effects.MethodsOne hundred and thirty-six patients were numbered according to the order of treatment: odd numbers were assigned to the intervention group(self-efficacy intervention group), and even numbers to the control group. General knowledge of orthodontics was explained to the control group. Beside the general knowledge of orthodontics, the intervention group was given self-efficacy intervention. The two groups were assessed using the self-rating anxiety scale(SAS), self-rating depression scale(SDS), general self-efficacy scale(GSES), and Wong-Baker faces pain scale throughout treatment.ResultsThe scores of Wong-Baker faces pain scale in intervention group were lower in the control compared with the intervention group; and the difference was statistically significant after 2 months of intervention(P<0 .05). a month after intervention, sas, sds, and gses scores of the intervention and control groups were significantly different(P<0 .05). a year after intervention, sas, sds, and gses scores of the intervention and the control groups were significantly different(P<0 .05). the satisfaction score in the intervention group is statistically higher than that in the control group(P<0 .05).ConclusionSelf-efficacy intervention can significantly reduce the morbidity of the mental health problem, improve the curative effect of orthodontics, enhance the patient compliance, and relieve pain in orthodontic patients.