As the development of genomics and transcriptomics, non-coding RNAs (ncRNAs) have been paid much attention. Previous studies have suggested that ncRNAs could regulate gene expression through several biological processes such as chromosome remodeling, transcription, and posttranscription translation. Abnormal versions of ncRNAs are closely related to several human diseases such as the generation and development of tumors. Therefore, ncRNAs may become novel biomarkers in the diagnosis, prognosis and target therapies of tumor research. As the essential role of ncRNAs playing in tongue squamous cell carcinoma (TSCC), the latest domestic and foreign literatures in TSCC progression were reviewed in this article.
