Polyetheretherketone(PEEK) is a new organic polymer compound. Considering its poor osteogenetic efficiency, PEEK has not been widely used in clinical settings. The disadvantages of PEEK can be overcome by combining PEEK with different components in a composite to increase its osteogenetic efficiency. Studies showed that PEEKhydroxyapatite composite exhibits good osteogenetic potency, but its brittleness is high and its mechanical properties are low. Carbon fiber can resolve these disadvantages. Fluorapatite PEEK and nano-titania-PEEK composites can also increase the osteogenetic efficiency of PEEK. Surface sandblasting, plasma spraying, laser and electric arc ion plating, chemical etching, growth factor promotion, and biological coating modification can effectively increase the biological activity and osteogenesis of PEEK, resulting in novel applications for prosthodontics and implantology. This article summarizes recent work on the osteogenetic performance of PEEK and its compositesto provide theoretical basis for its clinical application.