芫根总多糖对模拟高原缺氧小鼠的作用研究
Effects of total polysaccharides of Brassica rapa on hypoxic mice in simulated plateau
作者：谭秀娟;李古兵;张淼;何庆;
Author：
收稿日期： 年卷（期）页码：2020,35(02):-171-175
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：芫根总多糖;提取分离;高原缺氧;抗氧化;抗缺氧;脑;肺;急性高山病
Key words：
基金项目：中央高校科研业务资助项目(2682017ZT31)
中文摘要
目的研究芫根总多糖的抗氧化作用以及对模拟高原缺氧小鼠脑、肺的保护作用。方法采用低压低氧舱模拟海拔4000 m的高原环境,评估芫根总多糖的抗高原缺氧活性。结果连续7 d低氧暴露后,与常压常氧组比较,低压低氧模型组小鼠脑组织海马区、肺组织出现明显的病理损伤,脑、肺组织中的丙二醛(MDA)、乳酸(LD)的浓度和乳酸脱氢酶(LDH)的活性显著升高,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、总抗氧化能力(T-AOC)、ATP酶(ATPase)的活性显著降低。经过芫根总多糖给药处理后,高剂量组小鼠脑组织海马区、肺组织的病理损伤得到缓解,脑、肺组织中MDA、LDH和LD的活性显著降低,而SOD、GSH-Px、T-Aoc、ATPase的活性显著升高。结论芫根总多糖具有抗高原缺氧的作用,能保护模拟高原环境中缺氧小鼠的脑组织和肺组织,可能主要是通过升高机体自身抗氧化能力、降低氧自由基损伤、调节自身能量代谢来发挥抗高原缺氧的作用。
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