苦地丁的化学成分研究
Study on the chemical constituents of Corydalis bungeana
作者：李木子;张浩;朱粉霞;
Author：
收稿日期： 年卷（期）页码：2019,34(03):-120-126
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：苦地丁;化学成分;分离鉴定;生物碱;指纹图谱;二氢血根碱;乙酰紫堇灵;血根碱;紫堇灵;原阿片碱;延胡索乙素
Key words：
基金项目：国家自然科学基金资助项目(批准号:81473430)
中文摘要
目的研究苦地丁乙醇提取物中的化学成分。方法利用萃取和硅胶柱层析分离和纯化苦地丁乙醇提取物,对分离得到的化合物进行理化性质表征和波谱结构鉴定。结果从苦地丁乙醇提取物中分离得到7个化合物,分别鉴定为:二氢血根碱(Ⅰ)、乙酰紫堇灵(Ⅱ)、血根碱(Ⅲ)、紫堇灵(Ⅳ)、原阿片碱(Ⅴ)、延胡索乙素(Ⅵ)、1,2,3,4,4α,9β-hexahydro-5-(4-methoxy-1,4-dioxobutyl)-2,2,8-trimethyl-,(4αS,9βR)-5H-pyrido[4,3-b]indolium(Ⅶ)。结论化合物Ⅶ为首次从苦地丁植物中分离得到。
参考文献
[1]中国科学院中国植物志编辑委员会.中国植物志[M].北京:科学出版社,1983:32.
[2]中华人民共和国国家药典委员会.中国药典[S].一部.北京:中国医药科技出版社,2015:201.
[3]肖扬,杨春娟,钟明亮,等.苦地丁化学成分研究(英文)[J].天然产物研究与开发,2013,25(12):1665-1668,1689.
[4]郑建芳,秦民坚,郑昱,等.苦地丁生物碱的化学成分[J].中国药科大学学报,2007,38(2):112-114.
[5]易延逵,陈志良,邓虹珠.中药指纹图谱的研究评析[J].中成药,2006,28(8):1192-1197.
[6]顾英,冯怡,李玉敏.指纹图谱在中药物质基础研究中的应用[J].中成药,2007,29(7):1048-1051.
[7]白雪梅,乔春林,黄冕,等.素心腊梅种子中生物碱成分的研究[J].华西药学杂志,2016,31(6):611-614.
[8]Tani C,Nagakura N,Nattori S,et al.Studies on the alkaloids of Papaveraceous plants.XIX.Alkaloids of Corydalis koidzumiana Ohwi[J].Yakugaku Zasshi,1974,94(7):844-851.
[9]Oechslin SM,K9nig GM,Oechslinmerkel K,et al.An nmr study of four benzophenanthr-idine alkaloids[J].J Natural Products,1991,54(54).519-524.
[10]Niu L,Xie Z,Cai T,et al.Preparative isolation of alkaloids from Corydalis bungeana Turcz.by high-speed countercurrent chromatography using stepwise elution[J].J Separation Sci,2011,34(9):987-994.
[11]Takao N,Iwasa K,Kamigauchi M,et al.Studies on the alkaloids of Papaveraceous plants.XXX.Conformational analysis of some hydro-benzo[c]phenanthridine-type alkaloids[J].Chem Pharm Bull,2008,26(6):1880-1889.
[12]Nonaka G,Okabe H,Nishioka I,et al.Alkaloids of Corydalis incisa Pers.I.On the nonphenolic tertiary bases[J].Yakugaku Zasshi J Pharm Soc Japan,1973,93(1):87-93.
[13]Miao F,Yang XJ,Zhou L.Structural modification of sanguinarine and chelerythrine and their antibacterial activity[J].Natural Product Res,2011,25(9):863-875.
[14]Tou2ek J,Dommisse R,Dostál J,et al.Configurations and conformations of sanguinarine and chelerythrine free bases stereoisomers[J].J Mol Struct,2002,613(1-3):103-113.
[15]Tani C,Nagakura N,Nattori S,et al.Studies on the alk aloids of Papaveraceous plants XIX.Alkaloids of Corydalis koidzumiana[J].Ohwi Yakugaku Zasshi,1974,94(7):844-851.
[16]Takao N,Iwsa K,Kamigauchi M,et al.Studies on th e alkaloids of Papaveraceous plants XXX.Conformational analysis of some hydrobenzo[c]phenanth ridine-type alkaloids[J].Chem Pharm Bull,1978,26(6):1880-1889.
[17]Nonaka G,Okabe H,Nishioka I,et al.Alkaloids of Corydalis incisa Pers.I.On the nonphenolic tertiary bases[J].Yakugaku Zasshi,1973,93(1):87-93.
[18]Ma WG,Yukiharu F,Satoshi T.Fungitoxic alkaloids from Hokkaido Corydalis species[J].Fitoterapia,1999,70(3):258-265.
[19]Aggarwal P,Varshney VK,Dayal R,et al.Isoquinoline alkaloids from ethno botanically important Dicentra paucinervia[J].Int J Chem Sci,2009,7(3):1841-1850.
[20]许翔鸿,王峥涛,余国奠,等.延胡索中生物碱成分的研究[J].中国药科大学学报,2002,33(6):483-486.
[21]Sturm S,Strasser EM,Stuppner H.Quantification of fumaria officinalis isoquinoline alkaloids by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry[J].JChromatog A,2006,1112(1-2):331-338.
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