1-磷酸鞘氨醇受体与肿瘤关系的研究进展
作者：郭峰;孙冬冬;郝兵;陈长海;汪维云;
Author：
收稿日期： 年卷（期）页码：2018,33(03):-328-333
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：1-磷酸鞘氨醇(S1P);1-磷酸鞘氨醇受体(S1PRs);细胞凋亡;血管生成;信号通路;肿瘤;靶点;作用机制;受体亚型;协同作用
Key words：
基金项目：
中文摘要
1-磷酸鞘氨醇(S1P)与G蛋白偶联受体结合形成S1PRs,对多种细胞过程如细胞增殖、凋亡、迁移、血管生成等进行调节,发挥多种生物活性。S1PRs的表达以及相关酶表达水平的变化将导致S1P水平的改变,从而在肿瘤发生发展过程中发挥重要的作用。不同S1PRs受体亚型间的协同作用,以及S1P/S1PRs信号通路和其他信号通路间的关联,也是肿瘤发生发展机制的重要研究内容。现综述了国内外近年来对S1PRs受体的研究进展,并展望其作为肿瘤治疗新靶点的前景。
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