老年人抗抑郁药临床应用的研究进展
作者：卢静;冯小荣;黄媛;徐家玥;徐珽;李幼平;
Author：
收稿日期： 年卷（期）页码：2018,33(04):-435-439
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：老年人;抗抑郁药;临床应用;5-羟色胺再摄取抑制剂;选择性5-羟色胺及去甲肾上腺素再摄取抑制剂;三环类抗抑郁药;新型抗抑郁药
Key words：
基金项目：四川省卫生和计划生育委员会历史普能项目(编号:16PJ331)
中文摘要
抑郁症为老年人常见疾病,多种老年疾病如心血管、呼吸和肿瘤疾病均可能伴发抑郁。老年人因病理、生理特点使抗抑郁药在体内的吸收、分布、代谢和排泄与成年人差异较大,且更易发生不良反应。文中综述了常用抗抑郁药的作用机制、适应症、体内药动学特点、剂量调整和常见不良反应等,比较不同抗抑郁药对老年抑郁症的疗效和安全性,旨在为老年抑郁患者合理选用抗抑郁药提供参考。
参考文献
[1]Chen Y,HA,While AE.Depression and related factors in older people in China:A systematic review[J].Rev Clin Gerontol,2012,22(1):52-67.
[2]Pollock B,Forsyth C,Bies R.The critical role of clinical pharmacology in geriatric psychopharmacology[J].Clin Pharmacol Ther,2009,85(1):89-93.
[3]Ackerman DL,Greenland S,Bystritsky A,et al.Side effects and time course of response in a placebo-controlled trial of fluoxetine for the treatment of geriatric depression[J].J Clin Psychopharmacol,2000,20(6):658-665.
[4]Garlow SJ,Kinkead B,Thase ME,et al.Fluoxetine increases suicide ideation less than placebo during treatment of adults with minor depressive disorder[J].J Psychiatr Res,2013,47(9):1199-1203.
[5]Gibiino S,Mori E,De Ronchi D,et al.Potential benefits of slow titration of paroxetine treatment in an elderly population:Eightweek results from a naturalistic setting[J].J Clin Psychopharmacol,2013,33(4):565-569.
[6]Rapaport MH,Lydiard RB,Pitts CD,et al.Low doses of controlled-release paroxetine in the treatment of late-life depression:A randomized,placebo-controlled trial[J].J Clin Psychiatry,2009,70(1):46-57.
[7]Dalery J,Honig A.Fluvoxamine versus fluoxetine in major depressive episode:A double-blind randomised comparison[J].Hum Psychopharmacol,2003,18(5):379-384.
[8]Strik JJ,Honig A,Lousberg R,et al.Cardiac side-effects of two selective serotonin reuptake inhibitors in middle-aged and elderly depressed patients[J].Int Clin Psychopharmacol,1998,(6):263-267.
[9]Warrington SJ.Clinical implications of the pharmacology of sertraline[J].Int Clin Psychopharmacol,1991,6 Suppl 2:11-21.
[10]Brenes GA,Williamson JD,Messier SP,et al.Treatment of minor depression in older adults:A pilot study comparing sertraline and exercise[J].Aging Ment Health,2007,11(1):61-68.
[11]Weintraub D,Rosenberg PB,Drye LT,et al.Sertraline for the treatment of depression in Alzheimer disease:Week-24outcomes[J].Am J Geriatr Psychiatry,2010,18(4):332-340.
[12]Lavretsky H,Reinlieb M,St Cyr N,et al.Citalopram,methylphenidate,or their combination in geriatric depression:A randomized,double-blind,placebo-controlled trial[J].Am J Psychiatry,2015,172(6):561-569.
[13]Rosenberg C,Lauritzen L,Brix J,et al.Citalopram versus amitriptyline in elderly depressed patients with or without mild cognitive dysfunction:A danish multicentre trial in general practice[J].Psychopharmacol Bull,2007,40(1):63-73.
[14]Fraguas R,da Silva Telles RM,Alves TC,et al.A doubleblind,placebo-controlled treatment trial of citalopram for major depressive disorder in older patients with heart failure:The relevance of the placebo effect and psychological symptoms[J].Contemp Clin Trials,2009,30(3):205-211.
[15]Chen YM,Huang XM,Thompson R,et al.Clinical features and efficacy of escitalopram treatment for geriatric depression[J].J Int Med Res,2011,39(5):1946-1953.
[16]Gorwood P,Weiller E,Lemming O,et al.Escitalopram prevents relapse in older patients with major depressive disorder[J].Am J Geriatr Psychiatry,2007,15(7):581-593.
[17]Bose A,Li D,Gandhi C.Escitalopram in the acute treatment of depressed patients aged 60 years or older[J].Am J Geriatr Psychiatry,2008,16(1):14-20.
[18]Mikami K,Jorge RE,Moser DJ,et al.Increased frequency of first-episode poststroke depression after discontinuation of escitalopram[J].Stroke,2011,42(11):3281-3283.
[19]Thase M,Asami Y,Wajsbrot D,et al.A meta-analysis of the efficacy of venlafaxine extended release 75-225 mg/day for the treatment of major depressive disorder[J].Curr Med Res Opin,2017,33(2):317-326.
[20]Mokhber N,Abdollahian E,Soltanifar A,et al.Comparison of sertraline,venlafaxine and desipramine effects on depression,cognition and the daily living activities in Alzheimer patients[J].Pharmacopsychiatry,2014,47(4-5):131-140.
[21]Kivrak Y,Güvenc TS,Akbulut N1,et al.Accelerated hypertension after venlafaxine usage[J].Case Rep Psychiatry,2014,2014:659715.
[22]Robinson M,Oakes TM,Raskin J,et al.Acute and long-term treatment of late-life major depressive disorder:Duloxetine versus placebo[J].Am J Geriatr Psychiatry,2014,22(1):34-45.
[23]Scuteri A,Modestino A,Fedullo F,et al.Depression treatment selectively modifies arterial stiffness in older participants[J].J Gerontol A Biol Sci Med Sci,2013,68(6):719-725.
[24]Wohlreich MM,Sullivan MD,Mallinckrodt CH,et al.Duloxetine for the treatment of recurrent major depressive disorder in elderly patients:Treatment outcomes in patients with comorbid arthritis[J].Psychosomatics,2009,50(4):402-412.
[25]Culang-Reinlieb ME,Sneed JR,Keilp JG,et al.Change in cognitive functioning in depressed older adults following treatment with sertraline or nortriptyline[J].Int J Geriatr Psychiatry,2012,27(8):777-784.
[26]Kok RM,Nolen WA,Heeren TJ.Venlafaxine versus nortriptyline in the treatment of elderly depressed inpatients:A randomised,double-blind,controlled trial[J].Int J Geriatr Psychiatry,2007,22(12):1247-1254.
[27]Mulsant BH,Pollock BG,Nebes R,et al.A twelve-week,double-blind,randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients[J].Am J Geriatr Psychiatry,2001,9(4):406-414.
[28]Schatzberg AF,Kremer C,Rodrigues HE,et al.Double-blind,randomized comparison of mirtazapine and paroxetine in elderly depressed patients[J].Am J Geriatr Psychiatry,2002,10(5):541-550.
[29]Hewett K,Chrzanowski W,Jokinen R,et al.Double-blind,placebo-controlled evaluation of extended-release bupropion in elderly patients with major depressive disorder[J].J Psychopharmacol,2010,24(4):521-529.
[30]Camargos EF,Louzada LL,Quintas JL,et al.Trazodone improves sleep parameters in Alzheimer disease patients:A randomized,double-blind,and placebo-controlled study[J].Am J Geriatr Psychiatry,2014,22(12):1565-1574.
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