抑制吗啡耐受的天然药物及其作用机制的研究进展
作者：何鑫;李轶聪;曾凡荣;
Author：
收稿日期： 年卷（期）页码：2018,33(04):-425-428
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：吗啡耐受;阿片受体;神经胶质细胞;天然药物;芍药苷;白藜芦醇;氧化苦参碱;姜黄素
Key words：
基金项目：
中文摘要
以吗啡为代表的阿片类药物在急性与慢性疼痛的治疗中扮演着重要的角色,同时,大量此类药物的应用会导致吗啡耐受,降低镇痛效果的同时,常导致如痛觉过敏甚至药物成瘾等严重后果,近年来在寻找增强吗啡镇痛效果药物的同时,也在研究抑制阿片类药物的成瘾、耐受和痛觉过敏等不良反应的辅助治疗药物。文中综述了吗啡的镇痛机制与耐受成因及天然药物对吗啡耐受形成的影响。
参考文献
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