白藜芦醇防治阿尔茨海默病的研究进展
作者：张丽景;汪晨净;杨战利;
Author：
收稿日期： 年卷（期）页码：2018,33(05):-561-564
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：白藜芦醇;阿尔茨海默病;β淀粉样蛋白;tau蛋白;抗氧化;沉默调节因子1;抗炎;神经保护
Key words：
基金项目：国家自然科学基金资助项目(批准号:81360490);;
中央高校基本科研业务费专项资金项目(31920150041);;
西北民族大学引进人才科研项目(xbmuyjrc201205)
中文摘要
阿尔茨海默病(AD)的特征性病理改变包括β淀粉样蛋白沉积和tau蛋白过度磷酸化,目前缺乏有效的治疗药物。白藜芦醇具有防治AD的作用,其机制包括抗氧化、激活SIRT1、抑制tau蛋白磷酸化和抗炎等。现对白藜芦醇防治AD的研究现状作一综述,以期为白藜芦醇防治AD的进一步研究提供参考。
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