具有核壳结构的位点特异性药物载体的制备与表征
Preparation and characterization of the site-specific core-shell structured nanoparticles for drug delivery application
作者：彭兴;凌英宏;杨晓玲;李福森;陈铁寓;
Author：
收稿日期： 年卷（期）页码：2018,33(05):-473-476
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：核壳结构;超顺磁性;位点特异性;药物载体;纳米载体;扫描电镜;透射电镜;吸附;水热反应
Key words：
基金项目：广西高校中青年教师基础能力提升项目(2017KY0130;2017KY0086)
中文摘要
目的制备具有核壳结构的药物纳米载体,表征载体的结构并研究其毒性和吸附性能。方法以水热合成法制备具有超顺磁性的纳米Fe_3O_4球,在其表面包覆MCM-41分子筛以形成具有核壳结构的药物载体。通过扫描电镜、透射电镜手段鉴定了中间体以及载体的结构,并测试了吸附能力。结果与结论所得纳米药物载体具有位点特异性,直径为550 nm,外壳中MCM-41分子筛的孔径约2. 82 nm,具有较大的比表面积,可用于药物分子的装载。
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