血管内皮生长因子在缺血性脑损伤后血管新生中的作用
作者：尹彩霞;邓媛媛;黄彬;龚其海;
Author：
收稿日期： 年卷（期）页码：2016,31(01):-103-107
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：血管内皮生长因子;血管通透因子;缺血性脑损伤;血管新生;研究进展
Key words：
基金项目：教育部新世纪优秀人才支持计划(NCET-11-0927);;
遵义医学院联合基金(黔科合J字LKZ[2011]27号)
中文摘要
缺血性脑损伤是一系列复杂的多环节的病理生理变化过程,其发病率、致残率及死亡率居高不下,是严重威胁人类健康的一类重大疾病。血管内皮生长因子(VEGF)又叫血管通透因子,是有效的促血管生成因子之一,通过与其受体结合促进内皮细胞增殖,加速新血管形成,增加血管通透性。缺血性脑损伤后VEGF及其受体在脑中高度表达,促进新血管生成、改善脑血流、减轻脑损伤,在血管新生中起着重要作用。文中综述了VEGF在缺血性脑损伤后血管新生中的研究进展。
参考文献
[1]Senger DR,Galli SJ,Dvorak AM,et al.Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid[J].Sci,1983,219(4587):983-985.
[2]Ferrara N,Henzel WJ.Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells[J].Biochem Biophy Res Commun,1989,161(2):851-858.
[3]Krupiński J,Kaluza J,Kumar P,et al.Some remarks on the growth-rate and angiogenesis of microvessels in ischemic stroke.Morphometric and immunocytochemical studies[J].Patologia polska,1992,44(4):203-209.
[4]Krupinski J,Kaluza J,Kumar P,et al.Role of angiogenesis in patients with cerebral ischemic stroke[J].Stroke,1994,25(9):1794-1798.
[5]Greenberg DA,Jin K.Vascular endothelial growth factors(VEGFs)and stroke[J].Cell Mol Life Sci,2013,70(10):1753-1761.
[6]赵丽静,刘亢丁.血管内皮细胞生长因子治疗缺血性脑卒中的新思路[J].中华临床医师杂志:电子版,2011,5(7):2022-2025.
[7]Nilsson I,Bahram F,Li X,et al.VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts[J].EMBO J,2010,29(8):1377-1388.
[8]Clifford RL,Deacon K,Knox AJ.Novel regulation of vascular endothelial growth factor-A(VEGF-A)by transforming growth factorβ1 requirement for smads,β-CATENIN,and GSK3β[J].J Biol Chem,2008,283(51):35337-35353.
[9]Park JE,Keller GA,Ferrara N.The vascular endothelial growth factor(VEGF)isoforms:Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF[J].Mol Biol Cell,1993,4(12):1317-1326.
[10]Leppnen VM,Prota AE,Jeltsch M,et al.Structural determinants of growth factor binding and specificity by VEGF receptor 2[J].Proc Natl Acad Sci,2010,107(6):2425-2430.
[11]Ferrara N,Gerber HP,Le Couter J.The biology of VEGF and its receptors[J].Nat Med,2003,9(6):669-676.
[12]Papadopoulos N,Martin J,Ruan Q,et al.Binding and neutralization of vascular endothelial growth factor(VEGF)and related ligands by VEGF Trap,ranibizumab and bevacizumab[J].Angiogenesis,2012,15(2):171-185.
[13]Waltenberger J,Claesson-Welsh L,Siegbahn A,et al.Different signal transduction properties of KDR and Flt1,two receptors for vascular endothelial growth factor[J].J Biol Chem,1994,269(43):26988-26995.
[14]Hosooka T,Nomura K,Ogawa W.Vascular endothelial growth factor-B as a therapeutic target to prevent ectopic fat deposition[J].J Diabetes Invest,2013,4(6):525.
[15]Takahashi H,Shibuya M.The vascular endothelial growth factor(VEGF)/VEGF receptor system and its role under physiological and pathological conditions[J].Clin Sci,2005,109:227-241.
[16]Zan L,Zhang X,Xi Y,et al.Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia–reperfusion[J].Neuroscience,2014,262:118-128.
[17]Fan X,Heijnen CJ,van der Kooij MA,et al.The role and regulation of hypoxia-inducible factor-1αexpression in brain development and neonatal hypoxic–ischemic brain injury[J].Brain Res Rev,2009,62(1):99-108.
[18]Medici D,Olsen BR.Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF[J].PLo S ONE,2012,7(8):e42913.
[19]Yan J,Zhou B,Taheri S,et al.Differential effects of HIF-1inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke[J].PLo S ONE,2011,6(11):e27798.
[20]Wu W,Chen X,Hu C,et al.Transplantation of neural stem cells expressing hypoxia-inducible factor-1α(HIF-1α)improves behavioral recovery in a rat stroke model[J].J Clin Neurosci,2010,17(1):92-95.
[21]Shvartsman D,Storrie-White H,Lee K,et al.Sustained delivery of VEGF maintains innervation and promotes reperfusion in ischemic skeletal muscles via NGF/GDNF signaling[J].Mol Ther,2014.
[22]Talwar T,Srivastava MVP.Role of vascular endothelial growth factor and other growth factors in post-stroke recovery[J].Ann Indian Academy Neurology,2014,17(1):1.
[23]Mima A,Qi W,King GL.Implications of treatment that target protective mechanisms against diabetic nephropathy[J].Semin Nephrol,2012,32(5):471-478.
[24]Wang J,Ikeda R,Che XF,et al.VEGF expression is augmented by hypoxia-induced PGIS in human fibroblasts[J].Int J Oncology,2013,43(3):746-754.
[25]黄越芳,庄思齐,陈东平,等.新生大鼠缺氧缺血性脑病模型脑组织新生血管形成及调控因素[J].中华儿科杂志,2004,42(3):210-214.
[26]Sun Y,Jin K,Xie L,et al.VEGF-induced neuroprotection,neurogenesis,and angiogenesis after focal cerebral ischemia[J].J Clin Invest,2003,111(12):1843-1851.
[27]Fu SP,He SY,Xu B,et al.Acupuncture promotes angiogenesis after myocardial ischemia through H3K9 acetylation regulation at VEGF gene[J].Plo S One,2014,9(4):e94604.
[28]Zhang ZG,Zhang L,Jiang Q,et al.VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain[J].J Clin Invest,2000,106(7):829-838.
[29]Tado M,Mori T,Fukushima M,et al.Increased expression of vascular endothelial growth factor attenuates contusion necrosis without influencing contusion edema after traumatic brain injury in rats[J].J Neurotrauma,2014,31(7):691-698.
[30]Wang Y,Han Y,Yang J,et al.Relaxant effect of all-transretinoic acid via NO-s GC-c GMP pathway and calciumactivated potassium channels in rat mesenteric artery[J].Am J Physiol Heart Circul Physiol,2013,304(1):H51-H57.
[31]Liu Q,Li J,Wang J,et al.Effects and mechanisms of chinese herbal medicine in ameliorating myocardial ischemia-reperfusion injury[J].Evid Based Complement Alternat Med,2013,2013.
[32]Tsoutsou PG,Koukourakis MI.Angiogenesis and bone metastasis:Implications for diagnosis,prevention and treatment,in bone metastases[J].Springer,2009:51-76.
[33]Zeng W,Yuan W,Li L,et al.The promotion of endothelial progenitor cells recruitment by nerve growth factors in tissueengineered blood vessels[J].Biomaterials,2010,31(7):1636-1645.
[34]Dzietko M,Derugin N,Wendland M,et al.Delayed VEGF treatment enhances angiogenesis and recovery after neonatal focal rodent stroke[J].Translational Stroke Res,2013,4(2):189-200.
[35]Yang J,Guo L,Liu R,et al.Neuroprotective effects of VEGF administration after focal cerebral ischemia/reperfusion:Dose response and time window[J].Neurochem Int,2012,60(6):592-596.
[36]Figley SA,Liu Y,Karadimas SK,et al.Delayed administration of a bio-engineered zinc-finger VEGF-A gene therapy is neuroprotective and attenuates allodynia following traumatic spinal cord injury[J].Plo S One,2014,9(5):e96137.
[37]Zheng XR,Zhang SS,Yang YJ,et al.Adenoviral vector-mediated transduction of VEGF improves neural functional recovery after hypoxia-ischemic brain damage in neonatal rats[J].Brain Res Bull,2010,81(4):372-377.
[38]Bellomo M,Adamo EB,Deodato B,et al.Enhancement of expression of vascular endothelial growth factor after adeno-associated virus gene transfer is associated with improvement of brain ischemia injury in the gerbil[J].Pharmacol Res,2003,48(3):309-317.
[39]Pereira LF,Martin P,Frattini F,et al.Double gene therapy with granulocyte colony-stimulating factor and vascular endothelial growth factor acts synergistically to improve nerve regeneration and functional outcome after sciatic nerve injury in mice[J].Neuroscience,2013,230:184-197.
[40]Oh JS,An SS,Gwak SJ,et al.Hypoxia-specific VEGFexpressing neural stem cells in spinal cord injury model[J].Neuroreport,2012,23(3):174-178.
[41]Zhu W,Mao Y,Zhao Y,et al.Transplantation of vascular endothelial growth factor-transfected neural stem cells into the rat brain provides neuroprotection after transient focal cerebral ischemia[J].Neurosurgery,2005,57(2):325-333.
【关闭】
