川芎-当归药对有效成分在缺血性脑卒中应用的研究进展
作者：刘亚鹭;徐士欣;张军平;张男男;崔亚男;曹澜澜;
Author：
收稿日期： 年卷（期）页码：2018,33(06):-550-553
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：川芎-当归药对;有效成分;川芎嗪;阿魏酸;藁本内酯;缺血性脑卒中;神经保护;多靶点治疗
Key words：
基金项目：国家自然科学基金资助项目(批准号:81373850、8177140337)
中文摘要
缺血性脑卒中的发病率、死亡率和致残率极高,其生理病理机制复杂,川芎-当归药对是临床治疗脑缺血卒中的常用药对,其功效物质基础或临床作用的有效活性成分主要包括川芎嗪、阿魏酸、藁本内酯、当归多糖等,能够影响中风缺血后的急性损伤,包括抗炎、抗氧化、抗凋亡、抑制钙超载等,亦能促进神经元再生和血管新生,体现了对缺血性脑卒中治疗的神经保护和恢复作用以及多靶点的治疗机制。
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