鼻用喷雾给药研究的新进展
作者：王梦娇;章艳;陈小林;王玮;
Author：
收稿日期： 年卷（期）页码：2016,31(04):-432-436
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：鼻喷雾剂;质量控制;高速影像雾粒分析;雾滴分布;喷雾形态;激光衍射法;微细粒子空气动力学检查
Key words：
基金项目：浙江省高等学校青年骨干教师访问工程师(B类)项目(编号:FW2012008)
中文摘要
文中比较分析了目前国内外鼻喷剂的质量控制内容、方法及原理,详细阐述了国外用于表征喷雾雾滴大小及分布的方法及原理,如高速影像雾粒分析、激光衍射雾粒动态分析、显微图像识别结合拉曼光谱分析,并分析了这3种方法各自的特点及适用性。通过喷雾给药后雾滴在呼吸道内沉降分布的研究,结合鼻喷给药装置的研究进展,指出了目前鼻腔喷雾给药研究的热点和难点。简要分析了中国鼻喷剂研究与国外研究间的差距,并对鼻喷给药的应用开发前景进行了展望。
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