Box-Behnken效应面法优化姜黄素正负离子固体脂质纳米粒的处方
Formulation optimization of curcumin-catanionic solid lipid nanoparticles by Box-Behnken designs
作者：刘碧林;朱照静;刘煜莹;熊俊雅;张景勍;
Author：
收稿日期： 年卷（期）页码：2017,32(05):-471-474
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：姜黄素;Box-Behnken效应面法;正负离子固体脂质纳米粒;乳化蒸发-低温固化法;包封率;载药量;处方优化;差示扫描量热法
Key words：
基金项目：重庆市科委项目(cstc2015jcyj BX0027)
中文摘要
目的采用Box-Behnken效应面法筛选姜黄素正负离子固体脂质纳米粒的最优处方。方法采用乳化蒸发-低温固化法制备姜黄素的固体脂质纳米粒,以固体脂质的质量、卵磷脂的质量和混合表面活性剂为考察对象,以包封率和脂质载药量为考察指标,利用3因素3水平Box-Behnken效应面设计法筛选姜黄素固体脂质纳米粒的最优处方。结果按最优处方制备固体脂质纳米粒的包封率为94.20%±2.55%、脂质载药量为3.49%±0.11%,平均粒径为194.9±12.0 nm,Zeta电位为-28.15±2.72 m V。结论采用Box-Behnken效应面法优化姜黄素正负固体脂质纳米粒的处方是有效、可行的。
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