丹参酮ⅡA脂质体的制备及对HepG2/ADR细胞增殖的抑制作用
Preparation of tanshinone ⅡA liposomes and its growth inhibitory effects on HepG2/ADR cells
作者：张兆颖;储婷;马伟从;闫碧涵;
Author：
收稿日期： 年卷（期）页码：2014,29(01):-33-35
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：丹参酮;脂质体;肝癌;多药耐药;增殖抑制
Key words：
基金项目：四川省科技支撑计划项目(编号:2011SZ0009)
中文摘要
目的研制丹参酮ⅡA(TanⅡA)脂质体,考察其对人肝癌HepG2/ADR阿霉素耐药细胞增殖的抑制作用。方法采用薄膜分散法制备TanⅡA脂质体,改良MTT法测定药物肿瘤细胞增殖的抑制作用。结果制备载药脂质体的平均粒径为68nm,Zeta电位为-23.4 mV;载药量与包封率分别为138.9±8.7μg·mL-1、97.4%±1.2%(n=3);与游离药物相比,TanⅡA脂质体对HepG2/ADR的增殖细胞有更强的抑制(P
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