紫杉醇血药浓度的监测及其群体药动学的初步研究
Primary study of therapeutic drug monitoring and population pharmacokinetics of Paclitaxel
作者：李东锋;高惠静;张华;王建华;
Author：
收稿日期： 年卷（期）页码：2014,29(05):-562-565
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：紫杉醇;血药浓度;群体药动学;非线性混合效应模型;高效液相色谱法
Key words：
基金项目：新疆医科大学第一附属医院药学专项基金(项目编号:2011YX03)
中文摘要
目的采用RP-HPLC测定肿瘤患者血浆中紫杉醇的浓度,初步建立紫杉醇个体化给药方案。方法采用蛋白沉淀法处理样品;RP-HPLC法色谱柱为Symmetry C18柱(150 mm×4.6 mm,5μm),流动相为甲醇-水-乙腈(23∶41∶36),流速1.0 mL·min-1,检测波长227 nm,柱温30℃。收集20例肿瘤患者静脉输注紫杉醇的57个血样,测定血药浓度。数据分析采用非线性混合效应模型法。结果紫杉醇0.008~2.06μg·mL-1与峰面积比值的线性关系良好(r=0.9998),日内及日间RSD均
参考文献
[1]吴玉玲,余红春,孔俏玲.紫杉醇类联合铂类在癌症治疗中的应用及相关护理[J].中国药房,2010,21(48):4583-4585.
[2]Kim SC,Yu J,Lee JW,et al.Sensitive HPLC method for quantitation of paclitaxel in biological samples with application to preclinical pharmacokinetics and biodistribution[J].J Pharm Biomed Anal,2005,39(1-2):170-176.
[3]钟皎,赵文艳,王丽萍.高效液相色谱法测定非小细胞肺癌患者血浆中紫杉醇浓度[J].中国医院药学杂志,2008,28(7):538-540.
[4]Joerger M,Huitema AD,Huizing MT,et al.Safety and pharmacology of paclitaxel in patients with impaired liver function:A population pharmacokinetic-pharmacodynamic study[J].Br J Clin Pharmacol,2007,64(5):622-633.
[5]Sheiner L B,Rosenberg B,Marathe VV.Estimation of population characteristics of pharmacokinetic parameters from routine clinical data[J].Pharmacokinet Biopharm,1997,25(2):445.
[6]Yano Y,Beal SL,Sheiner LB.Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check[J].J Pharmacokinet Pharmacodyn,2001,28(2):171-192.
[7]Ette EI.Stability and performance of a population pharmacokinetic model[J].J Clin Pharmacol,1997,37(6):486-495.
[8]Brendel K,Comets E,Laffont C,et al.Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide[J].Pharmaceuti Research,2006,23(9):2036-2049.
[9]Rowinsky EK,Gilbert MR,McGuire WP,et al.Sequences of taxol and cisplatin,a phaseⅠand pharmacologic study[J].J Clin Oncol,1991,9(9):1692-1703.
[10]赵香兰.临床药代动力学基础与应用[M].郑州:郑州大学出版社,2002:106.
【关闭】
