紫杉醇纳米混悬剂的制备与表征
Preparation and characterization of Paclitaxel nanosuspension
作者：程晓丹;王永禄;李学明;黄琴琴;王悦;毛利娟;
Author：
收稿日期： 年卷（期）页码：2011,26(02):-118-121
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：紫杉醇;纳米混悬剂;重结晶;高压均质
Key words：
基金项目：
中文摘要
目的制备紫杉醇纳米混悬剂,并表征其理化性质。方法采用重结晶结合高压均质法制备紫杉醇纳米混悬剂,以纳米粒的粒径和Zeta电位为指标,考察紫杉醇纳米混悬剂的影响因素,并对制得的纳米混悬剂进行表征。结果紫杉醇纳米混悬剂的粒径为214.4 nm,跨距为0.46,平均Zeta电位为-22.7 mV,体系稳定。结论制备的纳米混悬剂处方简单、工艺稳定。
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