Migrastatin母核的全合成
Study on synthesis process of Migrastatin
作者：唐柏杨;吴小艾;谢蒋平;钟川龙;范成中;
Author：
收稿日期： 年卷（期）页码：2011,26(02):-103-107
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：Migrastatin;Dies-Alder反应;Ferrier重排;合成
Key words：
基金项目：
中文摘要
目的改进Migrastatin母核的全合成工艺。方法以(4R,5R)-二甲基-2,3-邻异丙亚基-L-酒石酸酯为起始原料,经DIBALH还原、Pb(OAc)4催化重排、LiBH4还原、Dies-Alder反应、Ferrier重排以及水解生成关键中间体,再经GrubbsⅡ催化分子内二烯烃关环反应生成Migrastatin母核。结果与讨论经11步反应,Migrastatin的总收率为1.8%。
参考文献
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