丹参酮ⅡA在抗肿瘤治疗中的新进展
作者：荣丽雯;冯旭琴;李志平;
Author：
收稿日期： 年卷（期）页码：2015,30(02):-255-258
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：丹参酮ⅡA;凋亡;自噬;化疗增敏;逆转;信号通路;耐药;作用机制
Key words：
基金项目：四川省科技厅支撑计划基金(编号:2009FZ0063)
中文摘要
丹参酮ⅡA为丹参提取的菲醌类衍生物中的一种,是临床上治疗心血管疾病的主要药物。丹参酮ⅡA对肿瘤具有杀伤作用,能诱导肿瘤细胞分化、凋亡、自噬,抑制肿瘤新生血管生形成和肿瘤的转移,还可起到增敏化疗、逆转化疗耐药的作用,在增敏放疗方面前景广阔。其作用机制可能与抑制肿瘤细胞的DNA合成、干扰细胞有丝分裂、抑制抗凋亡蛋白生成、激活多种凋亡、自噬信号通路相关。
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