植物内生真菌次生代谢稳定性的探讨
作者：郭晓恒;马云桐;严铸云;万德光;
Author：
收稿日期： 年卷（期）页码：2010,25(02):-228-231
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：内生真菌;发酵;稳定性;次生代
Key words：
基金项目：
中文摘要
内生真菌是一种新型可再生资源,已经成为寻找新型先导化合物的源泉,也是中药资源开发利用的热点。内生真菌次生代谢的生物不稳定性以致迄今没有一株内生真菌能够进行工业化生产,已成为开发内生真菌资源的瓶颈。本文探讨内生真菌次生代谢的生物不稳定性产生的原因。
参考文献
[1]Schulz B,Boyle C,Draeger S,et al.Endophytic fungi:a source of novel biologically active secondary metabolites[J].Mycological Res,2002,106(9):996-1004.
[2]Lu H,Zou WX,Meng JC,et al.New bioactive metabolites pro-duced by Colletotrichum sp.,an endophytic fungus in Artemisiaannua[J].Plant Sci,2000,151(1):67-73.
[3]王梅霞,陈双林,闫淑珍,等.一株产黄酮银杏内生真菌的分离鉴定与培养介质的初步研究[J].南京师范大学学报:自然科学版,2003,26(1):106.
[4]张永杰,王建锋,黄耀坚,等.4种裸子植物内生真菌抗肿瘤菌株的筛选[J].厦门大学学报:自然科学版,2002,41(6):804.
[5]王梅霞,陈双林,霍娟.一株银杏内生真菌的分离及其产黄酮类物质的初步研究[J].工业微生物,2004,34(2):15.
[6]罗静,严铸云,郭晓恒,等.大狼毒内生真菌的分离、鉴定与抑菌活性研究[J].华西药学杂志,2007,22(4):380-382.
[7]严铸云,庞蕾,罗静,等.银杏内生真菌的分离及鉴定[J].华西药学杂志,2006,21(5):425-427.
[8]Guo B,Dai JR,Ng S,et al.Cytonic Acids A and B:Novel Tridep-side Inhibitors of hCMV Protease from the Endophytic Fungus Cy-tonaema Species[J].Nat Prod,2000,63(5):602-604.
[9]Krohn K,Florke U,Rao M S,et al.Metabolites from fungi15.New isocoumarins from an endophytic fungus isolated from the Canadian thistle Cirsium arvense[J].Nat Prod Lett,2001,15(5):353.
[10]Kongsaeree P,Prabpai S,Sriubolmas N,et al.Antimalarial di-hydroisocoumarins produced by Geotrichum sp.,an endophytic fungus of Crassocephalum crepidioides[J].J Nat Prod,2003,66(5):709.
[11]王军,佘志刚,姜广策,等.南中国海红树林海洋真菌2492号次级代谢产物研究[J].中山大学学报:自然科学版,2005,44(2):132.
[12]徐庆妍,黄耀坚,郑忠辉,等.Cytosporone B的分离纯化、结构鉴定及其生物活性的初步研究[J].厦门大学学报:自然科学版,2005,44(3):425.
[13]刘文哲,张爱新,Reinscheid U M.喜树内生菌与喜树碱的关系[J].西北植物学报,2003,23(7):1275-1277.
[14]Wagenaar MM,Corwin J,Strobel G,et al.Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella[J].J Nat Prod,2000,63:1692.
[15]Tan RX,Zou WX.Endophytes:a rich source of functional metab-olites[J].Nat Prod Rep,2001,18:448-459.
[16]Saikkonen K,li PW,Helander M,et al.Evolution of endophyte–plant symbioses[J].Trends in Plant Sci,2004,9(6):275-280.
[17]Hartmann T.Chemical ecology of pyrrolizidine alkaloids[J].Planta,2007:483-495.
[18]Schardl CL,Grossman RB,Nagabhyru P,et al.Loline alkaloids:Currencies of mutualism[J].Phytochemistry,2007,68(7):980-996.
[19]Wang J,Machado C,Panaccione DG,et al.The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass[J].Fungal Genetics and Biology,2004,41(2):189-198.
[20]Michelle E,Afkhami,Jennifer A.Rudgers.Symbiosis Lost:Im-perfect vertical transmission of fungal endophytes in grasses[J].Am Nat,2008,172:405-416.
[21]Requena.Plant signals and fungal perception during arbuscular mycorrhiza establishment[J].Phytochemistry,2007,68:33-40.
[22]Faulkner JR,Hussaini SR,Blankenship JD,et al.On the se-quence of bond formation in loline alkaloid biosynthesis[J].Chembiochem,2006,7:1078-1088.
[23]Minerdi1D,Bianciotto1V,Bonfante1P.Endosymbiotic bacteria in mycorrhizal fungi:from their morphology to genomic sequences[J].Plant and Soil,2002,244(1-2):211-219.
[24]Osteryoung KW,Jodi N.The Division of Endosymbiotic Organelles[J].Sci,2003,302(5651):1698-1704.
[25]Meike H,William M.Interspecific evolution:microbial symbio-sis,endosymbiosis and gene transfer[J].Environmental Micro-biology,2003,5(8):641-649.
[26]Cruz AF,Horii S,Ochiai S,et al.Isolation and analysis of bacteria associated with spores of Gigaspora margarita[J].J Applied Mi-crobiology,2008,104(6):1711-1717.
[27]Laila PPM,Christian H.Pathogenic fungus harbours endosymbiot-ic bacteria for toxin production[J].Nature,2005,437(6):884-888.
[28]龙良鲲,姚青,艾云灿,等.丛枝茵根真菌伴生细菌的研究进展[J].生态学报,2007,27(12):5345-5351.
[29]Horgen P,Carvalho D,Sonnenberg A,et al.Chromosomal abnor-malities associated with strain degeneration in the cultivated mushroom Agaricus bisporus[J].Fungal Genetics and Biology,1996,20:229-141.
[30]Ryan MJ,Bridge PD,Smith D,et al.Plienotypic degeneration oc-curs during sector formation in Metarhizium anisopliae[J].J Ap-plied Microbiology,2002,93:163-168.
[31]Santos IM,Abrunhosa L,Venancio A,et al.The efect of culture preservation techniques on patulin and citrinin production by Pen-icillium expansum LirIl[J].Let in Applied Microbiology,2002,35:272-275.
【关闭】
