有序介孔材料SBA-15提高难溶性药物吡咯昔康溶出度的研究
Improvement of dissolution rate of piroxicam by assembling into SBA-15 mesoporous silica
作者：付廷明;乐康;陆瑾;王天瑶;郭立玮;
Author：
收稿日期： 年卷（期）页码：2010,25(02):-144-146
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：介孔材料;溶出度;吡咯昔康;SBA-15;难溶性药物
Key words：
基金项目：教育部博士点基金(20060315007);;
第四十五批中国博士后科学基金(20090451242)
中文摘要
目的采用与介孔材料复合的方式提高难溶性药物吡咯昔康的溶出度。方法通过X射线衍射、氮气吸附-脱附曲线、热分析及溶出度实验,观察吡咯昔康负载到SBA-15的表面情况。结果吡咯昔康溶解后自组装在介孔材料SBA-15的表面,紫外吸收与热重分析表明负载量为17%;X射线衍射、氮气吸附-脱附曲线、热分析及溶出度实验表明:吡咯昔康以极小非晶的形式负载在SBA-15的表面,负载后吡咯昔康的溶出度提高了144%。结论本研究为提高难溶性药物的溶出度提供了一条新途径。
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