盐酸托烷司琼口腔崩解片的制备
Preparation of Tropisetron hydrochloride orally disintegrating tablets
作者：陆军;黄晶晶;
Author：
收稿日期： 年卷（期）页码：2010,25(06):-668-671
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：盐酸托烷司琼;口腔崩解片;崩解时间;效应面图;等高线图;溶出度
Key words：
基金项目：南京工业大学校基金(编号:39728002)
中文摘要
目的制备并评价盐酸托烷司琼口腔崩解片。方法选择辅料,以口腔中崩解时间为考察指标,综合运用效应面图和等高线图对口腔崩解片处方进行优化,直接压片法压片后,考察盐酸托烷司琼口腔崩解片的溶出度。结果所用处方为5 mg盐酸托烷司琼、78 mg微晶纤维素、95 mg甘露醇、20 mg交联羧甲基纤维素钠、1.6 mg草莓香精、0.4 mg硬脂酸镁。口腔中崩解时间为22.8 s,溶出度为97.4%。结论采用直接压片法制备的盐酸托烷司琼口腔崩解片崩解时间短、溶出速度快。
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