突触前受体的药理学研究进展
作者：师晨霞,任雷鸣
Author：
收稿日期： 年卷（期）页码：2005,(05):-423-426
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：突触前受体;自调受体;旁调受体;突触前调节;钙通道;钾通道
Key words：
基金项目：
中文摘要
综述了突触前受体存在的证据、分类、调节和临床意义。突触前受体按不同的分类方法可分为突触前自调受体和旁调受体;抑制性和易化性突触前受体;G-蛋白偶联型和离子通道型突触前受体。突触前受体调节递质释放的机制,可能与钙通道、钾通道及囊泡释放复合物的调节有关。通过研制合适的突触前受体的激动剂或拮抗剂,适度调节神经末梢递质的释放,可达到控制或治疗多种疾病(如高血压、精神疾患、阿尔茨海默病、心肌缺血等)的目的。
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