超临界流体技术制备5-氟尿嘧啶聚乳酸微球
Preparation of 5-fluorouracil-poly(L-lactide) microparticles by supercritical fluids technique
作者：蒲曦鸣;陈爱政;康云清;尹光福;廖立;
Author：
收稿日期： 年卷（期）页码：2006,(06):-515-517
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：超临界流体强制分散溶液技术;氟尿嘧啶;聚乳酸;微球
Key words：
基金项目：教育部优秀青年教师基金资助项目(2002123)
中文摘要
目的以5-氟尿嘧啶(5-Fu)为模型药物,制备氟尿嘧啶聚乳酸微球。方法采用超临界流体强制分散溶液技术,将5-Fu微粒化,并制备5-Fu聚乳酸微球。通过扫描电镜、激光粒度仪检测微球外形及粒径分布;气相色谱法测定二氯甲烷的残留量;恒温振荡透析法检测药物的释放度。结果25℃时,微粒化后5-Fu的乙醇饱和溶液浓度为6.43 mg.m l-1,较原料药的2.32 mg.m l-1有显著提高;所制备载药微球球形较好,表面光滑,粒径分布窄,粒径范围0.615~1.990μm,平均粒径为0.980μm;二氯甲烷残留量为0.0046%;微球载药量为2.6%,包封率为17.8%,药物释放呈缓释模式,无突释效应。结论超临界流体强制分散技术是制备5-Fu聚乳酸微球的可行方法。
参考文献
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