消旋Schinzer酮合成工艺的改进
Improved synthetic process of the racemic Schinzer ketone
作者：杨黎;翁玲玲;林国强;王竝;
Author：
收稿日期： 年卷（期）页码：2007,(05):-529-532
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：埃坡霉素;Schinzer酮;还原;工艺改进
Key words：
基金项目：
中文摘要
目的优化还原产率,积累消旋Schinzer酮,为埃坡霉素(Epothilones)的全合成打下基础。方法消旋原料β羟基酯经LiAlH4还原,选择性丙叉保护和Dess-Martin氧化三步,得到消旋的Schinzer酮。结果与结论筛选还原条件,与文献类似物的还原相比,收率更高,试剂相对廉价。
参考文献
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