负载锌酞菁的SDC/TPGS混合胶束的制备与表征
Preparation and characterization of SDC/TPGS mixed micelles loaded with Zinc phthalocyanine
作者：卢小鸾;付阳洋;刘佳敏;喻昌木;杨敏;
Author：
收稿日期： 年卷（期）页码：2020,35(01):-1-6
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：光动力学疗法;锌酞菁;脱氧胆酸钠;D-α生育酚聚乙二醇琥珀酸酯;超分子自组装;混合胶束;单线态氧;体外评价
Key words：
基金项目：国家自然科学基金资助项目(批准号:21562014);;
贵州中烟科技项目(黔烟工技[2015]8号)
中文摘要
目的制备载锌酞菁(ZnPc)的混合胶束,并进行体外评价。方法以脱氧胆酸钠(SDC)和D-α生育酚聚乙二醇琥珀酸酯(TPGS)为载体材料,采用透析法制备载ZnPc的混合胶束。结果成功制得粒径约为90 nm的棒状ZnPc-SDC/TPGS混合胶束,Zeta电位为2.58±1.61 mV,包封率为91.07%±0.24%,载药量为14.38%±0.04%。混合胶束的形成或裂解控制了单线态氧(~1O_2)的产生,荧光的消失使更多的能量被转移到周围的氧气以产生更多~1O_2。体外释放动力学表明:ZnPc缓慢释放且无突释效应。结论 SDC和TPGS可通过超分子自组装形成混合胶束,体外评价表明:SDC/TPGS混合胶束是ZnPc潜在的优良载体。
英文摘要
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