五倍子与氟化钠对人工口腔生物膜细菌生长代谢的影响

Objective To compare the antibacterial effect between sodium fluoride andGalla Chinesisin biofilm model. To evaluate the feasibility of application ofGalla Chinesisin the clinical practice of caries prevention.Methods Streptococcus mu- tans,Streptococcus sanguis,Streptococcus salivariusandActinomyces naeslundiihad been chosen as the experimental bacteria. In the experiment, biofilmmodelwas constructed, and two agentswere added in the media. After a period of continuous culture, the number of bacteria adhering on the HA disc was examed, the planktonic pH in the flow cell was recorded continuously, and the morphology of the biofilmformed on theHAdisc was observed by SEM.Results ①Galla Chinesiscould inhibitthe growth of the four oral bacteria in the biofilm just as sodium fluoride.②Galla Chinesisand sodium fluoride could prevent the descent of the planktonic pH in the flow cell,butGalla Chinesiswas less efficient than sodium fluoride.③The biofilms formed after application ofGalla Chinesisand fluoride, but the bacterial cells had less matrixthan those applicatedwith sucrose.Conclusion Galla Chi- nesisis one kind of effective cariostatic natural agents.