溶血磷脂酸对骨组织细胞生物学调控功能的研究进展
Research progress on the biological regulatory function of lysophosphatidic acid in bone tissue cells
作者：吴湘楠, 马媛媛, 浩志超, 王航
Author：Wu Xiangnan, Ma Yuanyuan, Hao Zhichao, Wang Hang
收稿日期：2019-05-21 年卷（期）页码：2020,38(3):324-324-329
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：溶血磷脂酸,成骨细胞,破骨细胞,骨细胞,骨组织工程,
Key words：lysophosphatidic acid,osteoblast,osteoclast,osteocyte,bone tissue engineering,
基金项目：四川省科技计划(2019YFH0153);广东省基础与应用基础研究基金(2019A1515110810)
中文摘要
溶血磷脂酸（LPA）是一种结构简单的生物学磷脂,广泛存在于真核细胞组织和血浆中。作为胞外信号分子的LPA可以通过至少6种G蛋白偶联受体激活多条信号通路,产生广泛的细胞学效应,从而在组织发育、创伤愈合和肿瘤的发生发展中发挥重要作用。近年来研究表明,LPA对多种骨组织细胞亦表现出显著的生物学调控功能,对于骨组织的发育和修复重建具有重要影响,具备应用于骨组织工程的潜能。本文就LPA对骨组织细胞生物学调控功能的研究进展进行综述。
英文摘要
Lysophosphatidic acid (LPA) is a small phospholipid that is present in all eukaryotic tissues and blood plasma. As an extracellular signaling molecule, LPA mediates many cellular functions by binding to six known G protein-coupled receptors and activating their downstream signaling pathways. These functions indicate that LPA may play important roles in many biological processes that include organismal development, wound healing, and carcinogenesis. Recently, many studies have found that LPA has various biological effects in different kinds of bone cells. These findings suggest that LPA is a potent regulator of bone development and remodeling and holds promising application potential in bone tissue engineering. Here, we review the recent progress on the biological regulatory function of LPA in bone tissue cells.
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