Objective To study the feasibility and authenticity of repairing alveolar defects in alveolar cleft patients with osteoinduction active material（OAM） in clinic. Methods Twenty-seven cases of alveolar defect chosen from clinic were divided into two groups（test group and control group）. For test group（12 cases）, OAM was transplanted to repair the alveolar cleft. For control group（15 cases）, autogenous ilium cancellous bone were transplanted into the defect region to repair alveolar cleft. At 6 months after operation, CT and three-dimensional reconstruction were used to observe alveolar appearance, and the effect and clinical success rate of recover alveolar cleft by using different repair material were compared. Results In the 27 cases, all the maxillary continuity was restored except two of test group and two of control group. There was no significant difference between test group and control group regarding the clinical success rate of the alveolar cleft repair（P=1.000）. Conclusion OAM was used to repair the alveolar cleft that can result in new bone formations and the burgeon of canines from the bone grafted areas. There is no significant difference between OAM and autogenous ilium cancellous bone regarding the effect of the alveolar cleft repair.
